Safety is a major cause of attrition in drug discovery and development 1,2 and is, thus, a key consideration when making decisions at the major transition points in the drug pipeline (Box 1).

The reductionist approach to science will continue to play an important role in scientific inquiry and progress. However, there is increasing interest across disciplines in studying the multiple ...

Quantitative systems pharmacology (QSP) is a field of biomedical research that aims to model the mechanisms behind disease progression and quantify the pharmacokinetics and pharmacodynamics of ...