Background Most patients with biliary tract cancer (BTC) do not derive durable clinical benefit (DCB) from immune checkpoint inhibitors (ICIs), underscoring the urgent need for predictive biomarkers.

Abstract: Single-cell RNA sequencing (scRNA-seq) has profoundly reshaped our understanding of cellular diversity and functionality; however, accurate cell-type annotation is required for biological ...

The authors established a useful syndetome differentiation protocol from human induced pluripotent stem cells, guided by single-cell transcriptomic analysis. Their findings could significantly impact ...

Single-cell transcriptomics has revolutionised our understanding of the cellular complexity underlying neurodegenerative disorders by enabling the high-resolution profiling of individual brain cells.

Cervical Squamous Cell Carcinoma (CSCC) is the most common form of cervical cancer and represents a significant area of research in oncology. CSCC is often diagnosed at advanced stages, where ...

The single-cell genomics industry does not stop advancing, with a steady stream of new companies, kits, acquisitions, and more. One new company, ArgenTag, was founded in Argentina during the COVID-19 ...

This manuscript by Kaur et al. identifies differential gene expression in distinct cell populations, specifically myeloid and lymphoid cells, following short-term exposure to e-cigarette aerosols with ...

scRNA transcriptomics was done using BD Rhapsody (BD Biosciences, #633701) as per the manufacturer protocol followed by sequencing. In brief, 10–15 mL of peripheral blood was collected from patients ...

Abstract: Aging progresses unevenly across cells, making chronological age an incomplete measure of biological decline. Aging clocks, machine learning models trained on molecular features, offer a ...

If you're serving hard time inside a California prison, you'll often find yourself stuck in a cramped cell with a complete stranger. You hang a bedsheet to manufacture the semblance of privacy between ...

Background: Lung tissue exhibits intricate spatial organization and dynamic cellular interactions. However, the molecular mechanisms underlying pulmonary arterial hypertension (PAH) remain poorly ...

A comprehensive review article titled “Bioinformatics perspectives on transcriptomics: A comprehensive review of bulk and single-cell RNA sequencing analyses,” published in Quantitative Biology, ...