A new multiplex immunofluorescence workflow using standard laboratory equipment and open-source software enables detailed ...

无颌脊椎动物七鳃鳗的大脑相对简单，了解其工作原理可能为脊椎动物大脑进化提供宝贵见解。研究者结合单核RNA测序和空间转录组学技术，构建了成年七鳃鳗大脑的三维图谱。

Study: Common polyethylene microplastics may worsen fatty liver disease. In mice on high-fat diets, exposure doubled liver ...

Researchers at The University of Texas MD Anderson Cancer Center have developed a spatial map of muscle-invasive bladder ...

The gut microbiome is not a mere spectator but an active player in colorectal cancer (CRC), driving tumor initiation and ...

Spatial omics technologies provide revolutionary insights into complex tissues, offering key information about their organization, structure and function. These approaches have advanced research in ...

The heart is a structurally complex organ where function is intimately tied to the precise spatial organization of diverse cell types. While single-cell RNA sequencing (scRNA-seq) has revolutionized ...

Abstract: Spatial transcriptomics technology enables researchers to acquire both spatial location information and gene expression data within tissues, providing new perspectives for understanding ...

Here, we present Randomized Spatial PCA (RASP), a novel spatially aware dimensionality reduction method for spatial transcriptomics (ST) data. RASP is designed to be orders-of-magnitude faster than ...

In 2021, a technology developed at University of Michigan, called Seq-Scope, revolutionized the ability to map gene activity within intact tissue at microscopic resolution, enabling researchers to ...

The rapid development of spatial transcriptomics (ST) technologies has greatly advanced the understanding of gene expression, tissue architecture, cellular composition, and disease mechanisms within ...